Which factor best guides the timing of decontamination and antidotal therapy in acetaminophen toxicity?

Which factor best guides the timing of decontamination and antidotal therapy in acetaminophen toxicity?

• A. Only the amount ingested.
• B. Time since ingestion and onset of signs; early decontamination and NAC administration.
• C. Weight-based dosing dictates therapy.
• D. Decontamination is never indicated.

Answer: (B)